Drug Information

Drug General Information
Drug ID
D0QI8I
Former ID
DNC000413
Drug Name
CGS 8515
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545304]
Structure
Download
2D MOL

3D MOL
Formula
C18H13NO4
Canonical SMILES
COC(=O)C1=CC=CC=C1NC2=CC(=O)C(=O)C3=CC=CC=C32
InChI
1S/C18H13NO4/c1-23-18(22)13-8-4-5-9-14(13)19-15-10-16(20)17(21)12-7-3-2-6-11(12)15/h2-10,19H,1H3
InChIKey
PEJZAKFAABRDEN-UHFFFAOYSA-N
CAS Number
CAS 114832-13-2
PubChem Compound ID
163944
PubChem Substance ID
10255299, 15346213, 46238256, 57350254, 79124006, 103828796, 113452851, 117552749, 125742382, 134339843, 135119310, 140348598, 162276345, 162777252, 229303753, 245953453
SuperDrug ATC ID
P01CX03
SuperDrug CAS ID
cas=070052129
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [537697]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545304Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002765)
Ref 537697Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. Biochim Biophys Acta. 1988 Apr 15;959(3):332-42.

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