Drug General Information
Drug ID
D0QP7C
Former ID
DNC006827
Drug Name
4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528261]
Structure
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2D MOL

3D MOL

Formula
C15H10N2O4
Canonical SMILES
C1=CC=C(C=C1)C2=C(C3=C(C=CC(=C3)[N+](=O)[O-])NC2=O)O
InChI
1S/C15H10N2O4/c18-14-11-8-10(17(20)21)6-7-12(11)16-15(19)13(14)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19)
InChIKey
FHJYCGCXAYLWFD-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Fatty acid synthase Target Info Inhibitor [528261]
BioCyc Pathway Fatty acid biosynthesis initiation
Fatty acid elongation -- saturated
Palmitate biosynthesis
KEGG Pathway Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
AMPK signaling pathway
Insulin signaling pathway
Pathway Interaction Database p73 transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
PathWhiz Pathway Fatty Acid Biosynthesis
Reactome ChREBP activates metabolic gene expression
Activation of gene expression by SREBF (SREBP)
Fatty Acyl-CoA Biosynthesis
WikiPathways Fatty Acid Biosynthesis
Nuclear Receptors Meta-Pathway
Liver X Receptor Pathway
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Metabolism of water-soluble vitamins and cofactors
Integration of energy metabolism
Fatty acid, triacylglycerol, and ketone body metabolism
AMPK Signaling
References
Ref 528261Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. Epub 2006 Jun 19.3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Ref 528261Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. Epub 2006 Jun 19.3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.

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