Drug General Information
Drug ID	D0QQ7N
Former ID	DIB011069
Drug Name	TH-9229
Synonyms	Protectazem
Indication	Reperfusion injury [ICD10:I00-I99]		Terminated	[546444]
Company	Theratechnologies Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=O)N(c2c(S[C@@H]([C@@H]1O)c1ccc(cc1)OC)cccc2)CCNC
CAS Number	CAS 86408-40-4
Target and Pathway
Target(s)	Voltage-dependent P/Q-type calcium channel alpha-1A subunit	Target Info	Modulator	[546445]
	Voltage-dependent L-type calcium channel alpha-1D subunit	Target Info	Modulator	[546445]
	Voltage-dependent L-type calcium channel subunit alpha-1C	Target Info	Modulator	[546445]
	Voltage-dependent R-type calcium channel alpha-1E subunit	Target Info	Modulator	[546445]
	Voltage-dependent N-type calcium channel	Target Info	Modulator	[546445]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Synaptic vesicle cycle
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Long-term depression
	Taste transduction
	Type II diabetes mellitus
	Morphine addiction
	Nicotine addictionhsa04010:MAPK signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Cardiac muscle contraction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Circadian entrainment
	Insulin secretion
	GnRH signaling pathway
	Oxytocin signaling pathway
	Carbohydrate digestion and absorption
	Alzheimer's disease
	Amphetamine addiction
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
	Dilated cardiomyopathyhsa04010:MAPK signaling pathway
	Long-term potentiation
	Type II diabetes mellitushsa04010:MAPK signaling pathway
	Nicotine addiction
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Endogenous cannabinoid signaling
	GABA-B receptor II signalingP00003:Alzheimer disease-amyloid secretase pathway
	Nicotinic acetylcholine receptor signaling pathway
	5HT2 type receptor mediated signaling pathway
	Beta1 adrenergic receptor signaling pathway
	Beta2 adrenergic receptor signaling pathway
	Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Oxytocin receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Thyrotropin-releasing hormone receptor signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	GABA-B receptor II signaling
PathWhiz Pathway	Pancreas FunctionPW000564:Muscle/Heart Contraction
Reactome	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
	Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
	NCAM1 interactions
	Regulation of insulin secretionR-HSA-112308:Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways	Calcium Regulation in the Cardiac Cell
	Synaptic Vesicle Pathway
	Integration of energy metabolism
	Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
	Arrhythmogenic Right Ventricular Cardiomyopathy
	Alzheimers Disease
	NCAM signaling for neurite out-growth
	Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
	Nicotine Activity on Chromaffin CellsWP536:Calcium Regulation in the Cardiac Cell
References
Ref 546444	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)
Ref 546445	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)

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