TTD | Drug: D0R0TF

Drug General Information
Drug ID	D0R0TF
Former ID	DNC000336
Drug Name	BN50727
Drug Type	Small molecular drug
Indication	Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]		Discontinued in Phase 2	[545900]
Structure		Download 2D MOL 3D MOL
Formula	C26H23ClN6O2S
Canonical SMILES	CC1=NN=C2N1C3=C(C4=C(S3)CN(CC4)C(=O)NC5=CC=C(C=C5)OC)C(<br />=NC2)C6=CC=CC=C6Cl
InChI	1S/C26H23ClN6O2S/c1-15-30-31-22-13-28-24(18-5-3-4-6-20(18)27)23-19-11-12-32(14-21(19)36-25(23)33(15)22)26(34)29-16-7-9-17(35-2)10-8-16/h3-10H,11-14H2,1-2H3,(H,29,34)
InChIKey	DDJKTQDAEYPACV-UHFFFAOYSA-N
CAS Number	CAS 137281-23-3
PubChem Compound ID	65968
PubChem Substance ID	8190074, 14762806, 43122700, 50035300, 53722548, 57315866, 104335153, 117465119, 135025898, 160708916, 179149815, 198981758, 228249281
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
NetPath Pathway	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545900	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005290)

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Drug Information