Drug General Information
Drug ID
D0R1DP
Former ID
DIB012853
Drug Name
A-74283
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [545136]
Company
Abbott Laboratories
Structure
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2D MOL

3D MOL

Canonical SMILES
N1(C(=O)C2C(C1=O)C1C3C(C2C=C1)C=C3)CCCCN1C[C@H]2c3c(CC[<br />C@@H]2C1)cccc3OC.Cl
CAS Number
CAS 202754-51-6
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534558]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545136Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002258)
Ref 534558Cardiovascular activity of A-74283, a 5-hydroxytryptamine 1A agent, in the spontaneously hypertensive rat. Pharmacology. 1998 Jan;56(1):17-29.

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