Drug General Information
Drug ID	D0R1PZ
Former ID	DIB013949
Drug Name	F-15063
Synonyms	D2/D3 antagonists (psychosis/schizophrenia), Pierre Fabre
Drug Type	Small molecular drug
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Preclinical	[548528]
Company	Centre de Recherche Pierre Fabre
Structure		Download 2D MOL 3D MOL
Formula	C24H29NO2
Canonical SMILES	N(Cc1cc(ccc1)C1=CCCC1)CCOc1c2OC(Cc2ccc1)(C)C
CAS Number	CAS 936029-03-7
PubChem Compound ID	10248159
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Modulator
	D(2) dopamine receptor	Target Info	Modulator
KEGG Pathway	Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04015:Rap1 signaling pathway
	cAMP signaling pathway
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 548528	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026348)

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