Drug Information

Drug General Information
Drug ID
D0R3GW
Former ID
DIB020907
Drug Name
SB 649915
Synonyms
SB-649915
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542588]
Structure
Download
2D MOL
Formula
C26H29N3O3
InChI
InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30)
InChIKey
PJSUYRBCBFPCQW-UHFFFAOYSA-N
PubChem Compound ID
10296414
PubChem Substance ID
15303108, 22671002, 35613729, 78300635, 85229357, 99437190, 103446278, 135651013, 142835077, 143096643, 144239829, 162223696, 163361138, 223937964, 231201164, 245399039
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [527551]
5-hydroxytryptamine 1D receptor Target Info Antagonist [527551]
5-hydroxytryptamine 1B receptor Target Info Antagonist [527551]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 542588(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 76).
Ref 527551Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80.

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