TTD | Drug: D0R4TA

Drug General Information
Drug ID	D0R4TA
Former ID	DIB021041
Drug Name	tetronothiodin
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526869]
Structure		Download 2D MOL
Formula	C31H38O8S
InChI	InChI=1S/C31H38O8S/c1-17-10-8-9-13-21(32)12-7-5-4-6-11-20-14-18(2)19(3)15-31(20)28(35)24(30(38)39-31)25(33)22-16-40-27(23(17)22)26(34)29(36)37/h4-9,14,17,19-23,27,32,38H,10-13,15-16H2,1-3H3,(H,36,37)/b6-4+,7-5+,9-8+
InChIKey	RMYJUZDMOJDYES-SFYXYOTASA-N
PubChem Compound ID	54695534
PubChem Substance ID	14911144, 51378355, 57370031, 135229201, 135651252
Target and Pathway
Target(s)	Gastrin/cholecystokinin type B receptor	Target Info	Antagonist	[533945]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	CCKR signaling map ST
PathWhiz Pathway	Gastric Acid Production
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
	Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 526869	Tetronothiodin, a novel CCKB receptor ligand, antagonizes cholecystokinin-induced Ca2+ mobilization in a pituitary cell line. Eur J Pharmacol. 1992 Oct 6;221(1):99-105.
Ref 533945	Species specificity of pharmacological characteristics of CCK-B receptors. Neurosci Lett. 1993 Aug 6;158(1):1-4.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information