Drug General Information
Drug ID
D0R5GS
Former ID
DCL000813
Drug Name
Gepirone ER
Synonyms
Gepirona; Gepirone; Gepironum; Gepirona [Spanish]; Gepirone [INN]; Gepironum [Latin]; BMY 13805; MJ 13805; BMY-13805; MJ 13805-1; MJ-13805; 3,3-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]glutarimide; 4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-2,6-piperidinedione;4,4-dimethyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]piperidine-2,6-dione
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Terminated [536580]
Company
Fabre-Kramer; GSK
Structure
Download
2D MOL

3D MOL

Formula
C19H29N5O2
Canonical SMILES
CC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=NC=CC=N3)C
InChI
1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3
InChIKey
QOIGKGMMAGJZNZ-UHFFFAOYSA-N
CAS Number
CAS 83928-76-1
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N06AX19
SuperDrug CAS ID
cas=083928761
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [536580]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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