Drug Information

Drug General Information
Drug ID
D0R6BR
Former ID
DAP000686
Drug Name
Amobarbital
Synonyms
AMAL; Amasust; Amital; Amobarbitale; Amobarbitalum; Amobarbitone; Amospan; Amybal; Amylbarbitone; Amylobarbital; Amylobarbitone; Amytal; Barbamil; Barbamyl; Binoctal; Dorlotyn; Dormytal; Eunoctal; Isomyl; Isomytal; Mylodorm; Pentymal; Pentymalum; Robarb; Schiwanox; Sednotic; Somnal; Stadadorm; Sumital; Talamo; Amobarbital suppository dosage form; Amobarbitale [DCIT]; Barbamyl acid; Component of Dexamyl; Ethylisopentylbarbituric acid; Isoamylethylbarbituric acid; Amobarbital [INN:JAN]; Amobarbitalum [INN-Latin]; Component of 15-90; Component of Amo-Dextrosule; Component of Q-Caps; Isomytal (TN); Amobarbital (JP15/INN); 5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-(3-methylbutyl)barbituric acid;5-Ethyl-5-isoamylbarbituric acid; 5-Ethyl-5-isoamylmalonyl urea; 5-Ethyl-5-isopentylbarbituric acid; 5-Ethyl-5-isopentylbarbitursaeure; 5-Isoamyl-5-ethylbarbituric acid; 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione; 5-ethyl-5-(3-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Drug Type
Small molecular drug
Indication Insomnia; Anxiety disorder [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52, 300, 311; ICD10:F51.0, G47.0, F32, F40-F42] Approved [550722], [551871]
Therapeutic Class
Hypnotics and Sedatives
Structure
Download
2D MOL

3D MOL
Formula
C11H18N2O3
Canonical SMILES
CCC1(C(=O)NC(=O)NC1=O)CCC(C)C
InChI
1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChIKey
VIROVYVQCGLCII-UHFFFAOYSA-N
CAS Number
CAS 57-43-2
PubChem Compound ID
2164
PubChem Substance ID
9739, 75927, 90916, 415152, 4436381, 7847621, 7978707, 8151471, 10527891, 11135452, 11336169, 11361408, 11462380, 11533324, 12587661, 12587662, 15415185, 29221343, 46508165, 47291211, 47891734, 48413208, 48414905, 49857182, 50381613, 53789674, 57321181, 87691678, 93167109, 103165869, 104299793, 124954079, 125308270, 126677737, 129480778, 134337975, 134970867, 137003749, 137240387, 138744645, 144206419, 160964641, 164835791, 175267584, 176262155, 179094982, 179225502, 198993173, 223366878, 223674396
ChEBI ID
ChEBI:2673
SuperDrug ATC ID
N05CA02
SuperDrug CAS ID
cas=000057432
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555], [537688]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 550722Drug information of Amobarbital, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 537688Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23.

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