Drug Information

Drug General Information
Drug ID
D0R8GR
Former ID
DCL000907
Drug Name
OPC-14523
Drug Type
Small molecular drug
Indication Bulimia nervosa; Severe mood disorders [ICD9: 296, 307.51; ICD10:F30-F39, F50.2] Phase 2 [536493]
Female sexual dysfunction [ICD9: 302.7; ICD10:F52] Phase 1 [536493]
Company
Otsuka Pharmaceutical and Vela Pharmaceuticals; Pharmos and Otsaku
Structure
Download
2D MOL

3D MOL
Formula
C23H28ClN3O2
Canonical SMILES
COC1=CC=CC2=C1CCC(=O)N2CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
InChI
1S/C23H28ClN3O2/c1-29-22-8-3-7-21-20(22)9-10-23(28)27(21)12-4-11-25-13-15-26(16-14-25)19-6-2-5-18(24)17-19/h2-3,5-8,17H,4,9-16H2,1H3
InChIKey
TZZGTNZBLPCBIS-UHFFFAOYSA-N
CAS Number
CAS 145969-30-8
PubChem Compound ID
9892540
PubChem Substance ID
14929017, 24177759, 45639475, 76899160, 85210146, 103242071, 103857092, 129338381, 134222714, 134339358, 137022791, 141232616, 230894837, 241036542, 242056946
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Modulator [552279]
5-hydroxytryptamine 1A receptor Target Info Modulator [552279]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBaseWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536493Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. Epub 2007 Aug 27.
Ref 552279Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.

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