Drug General Information
Drug ID	D0S0AF
Former ID	DIB001233
Drug Name	Bunazosin
Synonyms	Andante; E 015; DE-070; Detantol-R; E-1015; E-643
Drug Type	Small molecular drug
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Approved	[551871]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C19H28ClN5O3
Canonical SMILES	c1(nc(c2c(n1)cc(c(c2)OC)OC)N)N1CCN(C(=O)CCC)CCC1
PubChem Compound ID	115305
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Modulator	[527544], [551871]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527544	Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. Cardiovasc Drug Rev. 2005 Spring;23(1):43-56.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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