Drug Information

Drug General Information
Drug ID
D0S0XS
Former ID
DIB009192
Drug Name
SR-271425
Synonyms
BCN-326862; SW-71425; WIN-71425; 1-[2-(Diethylamino)ethylamino]-4-(formamidomethyl)-7-methoxy-9H-thioxanthen-9-one
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 1 [546998]
Structure
Download
2D MOL

3D MOL
Formula
C22H27N3O3S
Canonical SMILES
CCN(CC)CCNC1=C2C(=C(C=C1)CNC=O)SC3=C(C2=O)C=C(C=C3)OC
InChI
1S/C22H27N3O3S/c1-4-25(5-2)11-10-24-18-8-6-15(13-23-14-26)22-20(18)21(27)17-12-16(28-3)7-9-19(17)29-22/h6-9,12,14,24H,4-5,10-11,13H2,1-3H3,(H,23,26)
InChIKey
GWLFIMOOGVXSMZ-UHFFFAOYSA-N
CAS Number
CAS 155990-20-8
PubChem Compound ID
9909677
PubChem Substance ID
14879890, 24190389, 45981338, 80350336, 103349449, 103961334, 124954258, 128016260, 135288548, 137094503, 142818819, 144210553, 198965413, 224978273, 226481704
Target and Pathway
Target(s) Human DNA Target Info Binder [529950]
References
Ref 546998Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011907)
Ref 529950A phase I dose-escalation study of SR271425, an intravenously dosed thioxanthone analog, administered weekly in patients with refractory solid tumors. Am J Clin Oncol. 2009 Feb;32(1):9-14.

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