Drug General Information
Drug ID
D0S2HO
Former ID
DIB002634
Drug Name
Perillyl alcohol
Synonyms
Monoterpenes, University of Wisconsin; Perillyl alcohol, University of Wisconsin; Perillyl alcohol, WARF
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 2 [545708]
Company
University of Wisconsin-Madison
Structure
Download
2D MOL

3D MOL

Formula
C10H16O
Canonical SMILES
C(=C)(C1CC=C(CC1)CO)C
CAS Number
CAS 536-59-4
PubChem Compound ID
Target and Pathway
Target(s) Ras GTPase Target Info Modulator [543720]
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Reactome SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Insulin receptor signalling cascade
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
ErbB Signaling Pathway
Senescence and Autophagy in Cancer
TGF Beta Signaling Pathway
IL-2 Signaling Pathway
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Cascade
p38 MAPK Signaling Pathway
G Protein Signaling Pathways
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Extracellular vesicle-mediated signaling in recipient cells
IL-3 Signaling Pathway
Bladder Cancer
Signaling by ERBB4
Signaling by ERBB2
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by the B Cell Receptor (BCR)
RAF/MAP kinase cascade
Interleukin-2 signaling
Signaling by SCF-KIT
DAP12 interactions
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Gastrin-CREB signalling pathway via PKC and MAPK
Nanoparticle-mediated activation of receptor signaling
JAK/STAT
Aryl Hydrocarbon Receptor
PDGF Pathway
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
RalA downstream regulated genes
Prostate Cancer
Signaling Pathways in Glioblastoma
Leptin signaling pathway
TSH signaling pathway
Signaling by PDGF
Signaling by Insulin receptor
Signaling by FGFR
Signaling by EGFR
NGF signalling via TRKA from the plasma membrane
NCAM signaling for neurite out-growth
Integrin-mediated Cell Adhesion
Interleukin-3, 5 and GM-CSF signaling
Cell surface interactions at the vascular wall
References
Ref 545708Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004297)
Ref 543720(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2823).

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