Drug General Information
Drug ID	D0S2WC
Former ID	DIB011529
Drug Name	Nerisopam
Synonyms	EGIS-6775
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Discontinued in Phase 1	[544884]
Company	EGIS Gyogyszergyar RT
Structure		Download 2D MOL 3D MOL
Formula	C18H19N3O2
Canonical SMILES	N1=C(c2c(cc(c(c2)OC)OC)CC(=N1)C)c1ccc(N)cc1
CAS Number	CAS 102771-12-0
PubChem Compound ID	65875
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Agonist	[534238]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544884	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001415)
Ref 534238	Simultaneous determination of nerisopam, a novel anxiolytic agent showing polymorphic metabolism, and its N-acetyl metabolite from human plasma by a validated high performance liquid chromatographic method. J Chromatogr B Biomed Appl. 1996 Mar 29;678(1):63-72.

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