Drug Information

Drug General Information
Drug ID
D0S3TJ
Former ID
DNC003254
Drug Name
6-MORPHOLIN-4-YL-9H-PURINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551374]
Structure
Download
2D MOL

3D MOL
Formula
C9H11N5O
Canonical SMILES
C1COCCN1C2=NC=NC3=C2NC=N3
InChI
1S/C9H11N5O/c1-3-15-4-2-14(1)9-7-8(11-5-10-7)12-6-13-9/h5-6H,1-4H2,(H,10,11,12,13)
InChIKey
MEOMXKNIFWDDGZ-UHFFFAOYSA-N
PubChem Compound ID
76098
PubChem Substance ID
576076, 862467, 3277739, 4719452, 7969883, 24905384, 43131798, 47737194, 47811423, 50898243, 57706320, 60732307, 81116192, 84981749, 85266831, 89460432, 99445251, 103133387, 103578276, 104363433, 105975001, 117358207, 117522217, 124822178, 125780793, 128584441, 131035026, 131385174, 134381908, 135032485, 137083630, 137858716, 138431631, 143893198, 162103452, 162829870, 164223240, 170198942, 170481504, 179077094, 179334770, 181849705, 215774649, 223579483, 225020709, 225161114, 225249271, 226672508, 241058492, 252456112
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk1 Target Info Inhibitor [551374]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infection
Viral carcinogenesis
Pathway Interaction Database Fanconi anemia pathway
p73 transcription factor network
ATR signaling pathway
Circadian rhythm pathway
p53 pathway
Reactome Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways DNA Damage Response
Signaling by SCF-KIT
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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