TTD | Drug: D0S3YN

Drug General Information
Drug ID	D0S3YN
Former ID	DIB012322
Drug Name	FE-202158
Synonyms	V1a agonist (septic shock), Ferring; Vasopressin 1a agonist (septic shock), Ferring
Indication	Septic shock [ICD9: 785.52; ICD10:A41.9]		Phase 2	[523936]
Company	Ferring Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C46H73N13O11S2
Canonical SMILES	N(CC(=O)N)C(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1NC(<br />=O)[C@@H](NC(=O)[C@H](CCCC(=O)N)NC(=O)[C@@H](NC(=O)[C@@<br />H](NC(=O)[C@@H](N)CSSC1)Cc1ccccc1)[C@@H](C)CC)CC(=O)N)C<br />CCNC(C)C
PubChem Compound ID	53330936
Target and Pathway
Target(s)	Vasopressin V1a receptor	Target Info	Agonist	[532722]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
Reactome	Vasopressin-like receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523936	ClinicalTrials.gov (NCT01612676) Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock. U.S. National Institutes of Health.
Ref 532722	The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-33.

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Drug Information