Drug Information

Drug General Information
Drug ID
D0S4JK
Former ID
DCL000170
Drug Name
MLN8237
Synonyms
Alisertib
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 3 [523707], [542741]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C27H20ClFN4O4
InChI
InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
InChIKey
ZLHFILGSQDJULK-UHFFFAOYSA-N
PubChem Compound ID
24771867
PubChem Substance ID
49693830, 57107096, 99436914, 103651972, 103905632, 104120110, 123055410, 124757022, 125163826, 131477692, 131480698, 134223405, 134338845, 135263892, 135626804, 135727405, 136367323, 136920350, 137173580, 137276087, 141669651, 143499693, 144116244, 152064066, 152234949, 152258281, 152344273, 160647120, 160838255, 162011658, 162037455, 162202572, 163098799, 163403893, 164193986, 164339418, 172095365, 172918135, 174006392, 174525840, 180111921, 185998541, 188899555, 198972240, 198993425, 204398557, 223366121, 223382037, 223613049, 223705104
Target and Pathway
Target(s) Aurora kinase A Target Info Inhibitor [549980]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 523707ClinicalTrials.gov (NCT01482962) Alisertib (MLN8237) or Investigator's Choice in Patients With Relapsed/Refractory Peripheral T-Cell Lymphoma. U.S. National Institutes of Health.
Ref 542741(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7790).
Ref 549980Effect of Aurora A kinase inhibitor MLN8237 combined with rituximab on antitumor activity in preclinical B-cell non-Hodgkin's lymphoma models. Journal of Clinical Oncology, 2009:8553.

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