Drug Information

Drug General Information
Drug ID
D0S4MN
Former ID
DIB021155
Drug Name
veratridine
Synonyms
veratrine; 3-veratroylveracevine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539696]
Structure
Download
2D MOL
Formula
C36H51NO11
InChI
InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
InChIKey
FVECELJHCSPHKY-YFUMOZOISA-N
PubChem Compound ID
6280
PubChem Substance ID
8137895, 11445999, 43526946, 46530453, 48393489, 50062968, 50111382, 53788722, 78684425, 85788256, 85856318, 92309931, 99300845, 103072066, 103081921, 104045143, 104311613, 134972303, 135652724, 136046139, 137005967, 175607798, 184582578, 194154853, 198983944, 226433616, 241376167, 249583246, 252156874, 252402715, 252455655
Target and Pathway
Target(s) mRNA of SCN1A Target Info Activator [543880]
Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Activator [543881]
Sodium channel protein type 2 subunit alpha Target Info Activator [533513]
SCN8A sodium channel subunit Target Info Activator [543883]
Sodium channel protein type 5 subunit alpha Target Info Activator [531463]
Sodium channel protein type 4 subunit alpha Target Info Activator [534563]
Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Activator [529119]
Voltage-gated sodium channel subunit alpha Nav1.7 Target Info Activator [543884]
KEGG Pathway Dopaminergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 539696(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2626).
Ref 529119A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons. Pflugers Arch. 2008 Feb;455(5):929-38. Epub 2007 Oct 26.
Ref 531463Sodium channel comodification with full activator reveals veratridine reaction dynamics. Mol Pharmacol. 1990 Feb;37(2):144-8.
Ref 533513Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7.
Ref 534563Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8.
Ref 543880(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578).
Ref 543881(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580).
Ref 543883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583).
Ref 543884(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584).

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