Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S4SX
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| Former ID |
DNCL001837
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| Drug Name |
K-134
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| Drug Type |
Small molecular drug
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Phase 2 | [522473] | ||
| Company |
Kowa Pharmaceuticals America
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| Structure |
|
Download2D MOL |
|||
| Formula |
C8H11NO5S
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| Canonical SMILES |
CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)C
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| InChI |
1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
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| InChIKey |
FKENQMMABCRJMK-RITPCOANSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9972, 618291, 7980696, 10242577, 14847263, 15121712, 25622048, 29215246, 29308945, 47193857, 48416564, 50085946, 50148676, 57269561, 57343357, 85279331, 90444204, 92309083, 92717113, 96025218, 103163858, 103932643, 104372503, 108667192, 117668018, 124766368, 124812411, 126622488, 127859141, 131323571, 134222618, 134350930, 135009448, 135692345, 135693785, 135727108, 136974559, 137022389, 137981775, 144187536, 144207191, 160811130, 162107598, 162178761, 162630505, 164196445, 164814570, 169618960, 170465248, 174006239
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| Target and Pathway | |||||
| Target(s) | Phosphodiesterase (PDE) 3 | Target Info | Modulator | [531714], [544269] | |
| References | |||||
| Ref 531714 | A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication. J Vasc Surg. 2012 Feb;55(2):381-389.e1. | ||||
| Ref 544269 | K-134, a Phosphodiesterase 3 Inhibitor, Prevents Brain Damage by Inhibiting Thrombus Formation in a Rat Cerebral Infarction Model. PLoS One. 2012; 7(10): e46432. | ||||
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