Drug Information

Drug General Information
Drug ID
D0S5DY
Former ID
DNC001193
Drug Name
R-85355
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545061]
Structure
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2D MOL

3D MOL
Formula
C21H22ClN5O3
Canonical SMILES
CC1=NN(C(=O)N1N2CCN(CC2)C3=CC=C(C=C3)O)CC(=O)C4=CC=C(C=<br />C4)Cl
InChI
1S/C21H22ClN5O3/c1-15-23-26(14-20(29)16-2-4-17(22)5-3-16)21(30)27(15)25-12-10-24(11-13-25)18-6-8-19(28)9-7-18/h2-9,28H,10-14H2,1H3
InChIKey
VZSLWTZQSOCFIA-UHFFFAOYSA-N
PubChem Compound ID
56603786
PubChem Substance ID
134340416, 235585316
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [538009]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545061Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001998)
Ref 538009Topical R-85355, a potent and selective 5-lipoxygenase inhibitor, fails to improve psoriasis. Skin Pharmacol. 1996;9(5):307-11.

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