Drug Information

Drug General Information
Drug ID
D0S5FQ
Former ID
DIB000104
Drug Name
MCPP
Synonyms
1-(3-Chlorophenyl)piperazine
Drug Type
Small molecular drug
Indication Mood disorder [ICD10:F30-F39] Discontinued in Phase 2 [525381]
Structure
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2D MOL

3D MOL
Formula
C10H11ClO3
Canonical SMILES
Clc1cccc(c1)N2CCNCC2
InChI
1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
InChIKey
VHFVKMTVMIZMIK-UHFFFAOYSA-N
CAS Number
CAS 6640-24-0
PubChem Compound ID
7153
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [526978], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 525381Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats. Br J Pharmacol. 2011 Apr;162(8):1770-80.
Ref 526978mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology. 2004 Apr;46(5):663-71.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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