Drug Information

Drug General Information
Drug ID
D0S6KA
Former ID
DIB016345
Drug Name
CALANOLIDE A
Synonyms
NSC-675451; NSC-664737 (racemate); (+)-(10R,11S,12S)-12-Hydroxy-6,6,10,11-tetramethyl-4-propyl-6,10,11,12-tetrahydro-2H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one; (+)-Calanolide A
Drug Type
Small molecular drug
Indication Mycobacterium tuberculosis infection [ICD10:A15-A19] Phase 1 [521471]
Company
Sarawak MediChem Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C22H26O5
Canonical SMILES
CCCC1=CC(=O)Oc2c3C(O)C(C)C(C)Oc3c4C=CC(C)(C)Oc4c12
InChI
1S/C22H26O5/c1-6-7-13-10-15(23)26-21-16(13)20-14(8-9-22(4,5)27-20)19-17(21)18(24)11(2)12(3)25-19/h8-12,18,24H,6-7H2,1-5H3
InChIKey
NIDRYBLTWYFCFV-UHFFFAOYSA-N
CAS Number
CAS 142632-32-4
PubChem Compound ID
64972
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [526066]
References
Ref 521471ClinicalTrials.gov (NCT00005120) The Safety and Effectiveness of (+)-Calanolide A in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs. U.S. National Institutes of Health.
Ref 526066Calanolide A: a natural non-nucleoside reverse transcriptase inhibitor. BETA. 1999 Apr;12(2):8-9.

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