Drug Information

Drug General Information
Drug ID
D0S7LG
Former ID
DNCL002553
Drug Name
ARN-509
Synonyms
Arn-509 (AR inhibitor)
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 3 [524437]
Company
Aragon Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C21H15F4N5O2S
Canonical SMILES
CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C<br />4)C(F)(F)F)C#N)F
InChI
1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)
InChIKey
HJBWBFZLDZWPHF-UHFFFAOYSA-N
PubChem Compound ID
24872560
PubChem Substance ID
50127665, 57161266, 152159708, 152258720, 160647563, 162012009, 162108672, 162205209, 164045137, 165245619, 170501902, 174007290, 174531399, 185990492, 189024879, 198977777, 223388726, 223471410, 223705154, 224466409, 227174897, 242586422, 251962968, 252110202, 252160623, 252214876, 252455417
Drug Resistance Mutation (DRM)
DRM DRM Info
References
Ref 524437ClinicalTrials.gov (NCT01946204) A Study of ARN-509 in Men With Non-Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health.

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