Drug Information

Drug General Information
Drug ID
D0S7UD
Former ID
DNC010186
Drug Name
4-(1H-indol-5-yloxy)-5-styrylnicotinonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530390]
Structure
Download
2D MOL

3D MOL
Formula
C22H15N3O
Canonical SMILES
C1=CC=C(C=C1)C=CC2=C(C(=CN=C2)C#N)OC3=CC4=C(C=C3)NC=C4
InChI
1S/C22H15N3O/c23-13-19-15-24-14-18(7-6-16-4-2-1-3-5-16)22(19)26-20-8-9-21-17(12-20)10-11-25-21/h1-12,14-15,25H/b7-6+
InChIKey
IMMBFBPNPIRCBR-VOTSOKGWSA-N
PubChem Compound ID
45484993
Target and Pathway
Target(s) mRNA of Protein kinase C-theta Target Info Inhibitor [530390]
KEGG Pathway NF-kappa B signaling pathway
Vascular smooth muscle contraction
Tight junction
T cell receptor signaling pathway
Inflammatory mediator regulation of TRP channels
Adipocytokine signaling pathway
Measles
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
T cell activation
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
TCR signaling in na&#xef
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Downstream signaling in na&#xef
Reactome Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling events
WikiPathways TCR Signaling Pathway
Calcium Regulation in the Cardiac Cell
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Fc epsilon receptor (FCERI) signaling
Corticotropin-releasing hormone
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
TCR signaling
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysis
Apoptotic execution phase
References
Ref 530390Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Ref 530390Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.

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