Drug Information

Drug General Information
Drug ID
D0S7VH
Former ID
DNC000677
Drug Name
Gaster
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535660], [537406]
Structure
Download
2D MOL

3D MOL
Formula
C8H15N7O2S3
Canonical SMILES
C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
InChI
1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChIKey
XUFQPHANEAPEMJ-UHFFFAOYSA-N
CAS Number
CAS 76824-35-6
PubChem Compound ID
5702160
PubChem Substance ID
219459, 855518, 7847384, 7979217, 10321312, 11111194, 11111195, 11736775, 12013748, 14777800, 14900130, 14900131, 17405060, 24278442, 26719681, 26753575, 46386903, 47350438, 47425376, 47721689, 47957418, 48108291, 48244468, 48407560, 48415998, 49681730, 49698346, 49835099, 49846705, 50022089, 50100994, 50100995, 50106279, 50106280, 53777603, 57364911, 76715592, 77320398, 81093272, 85211955, 85220228, 85231052, 87558227, 90340682, 90501992, 91704175, 92125054, 92303791, 92308237, 92308848
ChEBI ID
ChEBI:4975
SuperDrug ATC ID
A02BA03
SuperDrug CAS ID
cas=076824356
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [535660], [537406]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 537406Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine. BMC Gastroenterol. 2009 Jun 2;9:40.
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 537406Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine. BMC Gastroenterol. 2009 Jun 2;9:40.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.