Drug Information

Drug General Information
Drug ID
D0S7WX
Former ID
DAP001543
Drug Name
Vitamin A
Synonyms
ACON; ATAV; Afaxin; Agiolan; Agoncal; Alin; Alphalin; Alphasterol; Anatola; Aoral; Apexol; Apostavit; Aquasynth; Atars; Avibon; Avita; Avitol; Axerol; Axerophthol; Axerophtholum; Biosterol; Cylasphere; Dofsol; Epiteliol; LPK; Myvpack; Ophthalamin; Prepalin; Retinol; Retinolo; Retinolum; TROL; Testavol; Thalasphere; Vaflol; Vafol; Veroftal; Vitpex; Vogan; Wachstumsvitamin; Alcovit A; All Trans Retinol; Anatola A; Antixerophthalmic vitamin; Antixerophthalmisches Vitamin; Aquasol A Parenteral; Bentavit A; Chocola A; Disatabs Tabs; Dohyfral A; Homagenets Aoral; Homagenets aorl; Hydrovit A; Lard Factor; Mvc Plus; Oleovitamin A; Plivit A; Retinol solution; Retinolo [DCIT]; Retrovitamin A; Sehkraft A; Super A; Testavol S; Vitamin A alcohol; Vitamin A cryst; Vitamine A; Vitaminum A; Vitavel A; Zinosan N; Rovimix A 500; Vitamin A1; Vitamin A1 alcohol; A-Mulsal; A-Sol; A-Vitan; All-trans retinol; Anti-infective vitamin; Beta-Retinol; Retinol [INN:BAN]; Retinolum [INN-Latin]; Solu-A; Trans-Vitamin A alcohol; Trans-retinol; Vi-Alpha; Vi-a; Vi-alpha; Vio-A; Vitamin A (Feed); Vitamin A (USP); Vitamin A alcohol (VAN); Vitamin A1 alcohol, all trans; Vitamin-A; Vitamin-A alcohol; Vitamin-A alcohol solution; Vitamin-A1; Vitavel-A; Vogan-Neu; Vogan-nu; A-Vi-Pel; ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1); All-trans-Retinol; All-trans-Retinyl alcohol; All-trans-Vitamin A; All-trans-Vitamin A alcohol; All-trans-Vitamin A1; Del-VI-A; Hi-A-Vita; Nio-A-Let; Ro-a-vit; Trans-Retinol acid (Vitamin A); Vi-Dom-A; [11,12-3H]-Retinol; M.V.C. 9+3; M.V.I.-12; Retinol, all-trans-(8CI); Retin-11,12-t2-ol (9CI); Retinol-(cellular-retinol-binding-protein); Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol; All-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer
Drug Type
Small molecular drug
Indication Night blindness [ICD9: 368.6; ICD10:H53.6] Approved [537623], [540652]
Therapeutic Class
Vitamins
Structure
Download
2D MOL

3D MOL
Formula
C20H30O
InChI
InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
InChIKey
FPIPGXGPPPQFEQ-OVSJKPMPSA-N
CAS Number
CAS 11103-57-4
PubChem Compound ID
445354
PubChem Substance ID
3756, 416404, 603541, 821173, 824333, 826984, 838308, 842011, 3138738, 7890334, 8144182, 8149779, 10299682, 10532643, 11528329, 11537746, 12146301, 14714468, 14799924, 17389530, 24697570, 24890099, 24890100, 24899395, 26612235, 26680020, 26709666, 26710635, 26747393, 26747394, 26753109, 26753110, 36888084, 46393062, 46508191, 47193665, 47193688, 47208199, 47217041, 47217042, 47291361, 47440523, 48416515, 48422815, 48425698, 48484015, 50105638, 53788786, 56374000, 57404676
ChEBI ID
ChEBI:17336
SuperDrug ATC ID
A11CA01; D10AD02; R01AX02; S01XA02
SuperDrug CAS ID
cas=000068268
Target and Pathway
Target(s) Retinoic acid receptor RXR-gamma Target Info Binder [537623]
Retinoic acid receptor Target Info Binder [537623]
KEGG Pathway PPAR signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Small cell lung cancer
Non-small cell lung cancer
Pathway Interaction Database Regulation of Androgen receptor activity
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
a6b1 and a6b4 Integrin signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Adipogenesis
Nuclear Receptors
References
Ref 537623Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.
Ref 540652(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4053).
Ref 537623Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.

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