Drug Information

Drug General Information
Drug ID
D0S8TD
Former ID
DAP000677
Drug Name
Methohexital
Synonyms
Brevital; Brietal; Enallynymall; Enallynymalum; Methodrexitone; Methohexitalum; Methohexitone; Metoesital; Metohexital; Metoesital [DCIT]; Brevital (TN); Methohexital, Monosodium Salt; Methohexitalum [INN-Latin]; Metohexital [INN-Spanish]; Methohexital (USP/INN); Alpha-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituricacid; (+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid; 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione; 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-prop-2-en-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione; 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid; 5-hex-3-yn-2-yl-1-methyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [538449], [542249]
Therapeutic Class
Anesthetics
Company
Par Sterile Products Llc
Structure
Download
2D MOL

3D MOL
Formula
C14H18N2O3
InChI
InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19)
InChIKey
NZXKDOXHBHYTKP-UHFFFAOYSA-N
CAS Number
CAS 151-83-7
PubChem Compound ID
9034
PubChem Substance ID
10046, 6595674, 7979932, 8156427, 10508872, 15221591, 29227653, 46507954, 47206715, 48416246, 50064561, 50254042, 57325389, 81065578, 85307820, 103165721, 104319372, 125536617, 126688136, 128778614, 131299968, 134337966, 134973427, 134992212, 137124318, 137261298, 160963820, 163259654, 164788538, 165235242, 175442208, 178103807, 179225908, 184545823, 206246060, 223660023, 226459709, 249943055, 252351630
SuperDrug ATC ID
N01AF01; N05CA15
SuperDrug CAS ID
cas=000151837
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 538449FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011559.
Ref 542249(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7233).
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.

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