Drug Information

Drug General Information
Drug ID
D0S9MU
Former ID
DAP000220
Drug Name
Rizatriptan
Synonyms
Risatriptan; Rizatriptanum; Rizatriptan benzoat; MK 462 free base; Maxalt (TN); Rizaliv (TN); Rizalt (TN); Rizatriptan (INN); Rizatriptan [INN:BAN]; N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine; N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine; N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
Drug Type
Small molecular drug
Indication Acute migraine [ICD9: 346; ICD10:G43] Approved [468161], [538326]
Therapeutic Class
Antiinflammatory Agents
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C15H19N5
InChI
InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
InChIKey
ULFRLSNUDGIQQP-UHFFFAOYSA-N
CAS Number
CAS 145202-66-0
PubChem Compound ID
5078
PubChem Substance ID
7380056, 7980527, 8153125, 15221855, 26612819, 26749916, 29224147, 46506557, 46530620, 48416524, 49830967, 49984083, 50173225, 57322597, 85209524, 92718843, 93166519, 96025171, 99373553, 103236413, 103941727, 104308214, 125001917, 125728524, 126621280, 126658125, 126667003, 129384422, 131299041, 134337535, 134358454, 135110600, 135650905, 135684127, 136375513, 137002445, 139157639, 143494842, 144205087, 152036015, 152239970, 160964292, 162011662, 172091432, 174007052, 174477513, 174527522, 175266240, 176484738, 179116883
ChEBI ID
ChEBI:48273
SuperDrug ATC ID
N02CC04
SuperDrug CAS ID
cas=144034800
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [535607]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 468161(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 51).
Ref 538326FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 077263.
Ref 535607An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy. Proc West Pharmacol Soc. 2002;45:199-210.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.