Drug Information

Drug General Information
Drug ID
D0T1SF
Former ID
DIB004282
Drug Name
PNU-109291
Synonyms
U-109291
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Terminated [540203], [546823]
Company
Pharmacia & Upjohn Inc
Structure
Download
2D MOL

3D MOL
Formula
C24H31N3O3
InChI
InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m0/s1
InChIKey
UDLSEQDYARNKTL-QHCPKHFHSA-N
CAS Number
CAS 187665-60-7
PubChem Compound ID
9909448
PubChem Substance ID
14879650, 24190214, 45981109, 53788712, 76589092, 103264715, 103959742, 129352746, 135698829, 137005648, 178100285, 231407424, 241375998, 249617607, 252156606
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Agonist [531636], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540203(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3228).
Ref 546823Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010481)
Ref 531636Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn. Br J Pharmacol. 2012 Mar;165(6):1956-65.
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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