Drug Information

Drug General Information
Drug ID
D0T2MN
Former ID
DIB000771
Drug Name
Z-300
Synonyms
2-(2-Hydroxyethylsulfanyl)-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide 2-(4-hydroxybenzoyl)benzoate
Drug Type
Small molecular drug
Indication Gastric ulcer [ICD9: 531; ICD10:K25] Discontinued in Phase 1 [544901]
Structure
Download
2D MOL

3D MOL
Formula
C19H30N2O3S
Canonical SMILES
C1CCN(CC1)CC2=CC(=CC=C2)OCCCNC(=O)CSCCO
InChI
1S/C19H30N2O3S/c22-11-13-25-16-19(23)20-8-5-12-24-18-7-4-6-17(14-18)15-21-9-2-1-3-10-21/h4,6-7,14,22H,1-3,5,8-13,15-16H2,(H,20,23)
InChIKey
ZRVDLLKTYZXNAD-UHFFFAOYSA-N
CAS Number
CAS 127966-78-3
PubChem Compound ID
124488
PubChem Substance ID
10241091, 14901702, 29304505, 49859667, 50912705, 57340931, 85210064, 104420910, 126435459, 129946044, 135081886, 230519458
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [526779], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 544901Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001448)
Ref 526779Effects of a new histamine H2-receptor antagonist, Z-300, on gastric secretion and gastro-duodenal lesions in rats: comparison with roxatidine. Jpn J Pharmacol. 1992 Jul;59(3):275-89.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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