Drug General Information
Drug ID	D0T3HK
Former ID	DNC009123
Drug Name	1-(pyridin-4-yl)piperazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530029]
Structure		Download 2D MOL 3D MOL
Formula	C9H13N3
Canonical SMILES	C1CN(CCN1)C2=CC=NC=C2
InChI	1S/C9H13N3/c1-3-10-4-2-9(1)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChIKey	OQZBAQXTXNIPRA-UHFFFAOYSA-N
PubChem Compound ID	70517
Target and Pathway
Target(s)	Phospholipase D1	Target Info	Inhibitor	[530029]
BioCyc Pathway	Phospholipases
KEGG Pathway	Glycerophospholipid metabolism
	Ether lipid metabolism
	Metabolic pathways
	Ras signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Endocytosis
	Fc gamma R-mediated phagocytosis
	Glutamatergic synapse
	GnRH signaling pathway
	Pathways in cancer
	Pancreatic cancer
	Choline metabolism in cancer
PANTHER Pathway	Angiogenesis
	Ras Pathway
Pathway Interaction Database	RhoA signaling pathway
	Arf6 trafficking events
	CDC42 signaling events
	Arf6 downstream pathway
	mTOR signaling pathway
	ErbB1 downstream signaling
	IL8- and CXCR1-mediated signaling events
	Alpha-synuclein signaling
Reactome	Role of phospholipids in phagocytosis
WikiPathways	EGF/EGFR Signaling Pathway
	TSH signaling pathway
References
Ref 530029	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Ref 530029	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

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