Drug General Information
Drug ID
D0T3JW
Former ID
DCL001028
Drug Name
U-99194A
Synonyms
Pnu 99194A; U 99194; U 99194A; PNU-99194A; U-99194; (5,6-dimethoxyindan-2-yl)dipropylamine; 1H-Indan-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-, hydrochloride; 1H-Inden-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-, hydrochloride; 5,6-Dimethoxy-2-(dipropylamino)indan hydrochloride; 5,6-Dimethoxy-N,N-dipropyl-2,3-dihydro-1H-indan-2-amine; 5,6-Dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine hydrochloride; 5,6-dimethoxy-2-(di-n-propylamino)indan; 5,6-dimethoxy-n,n-dipropyl-2,3-dihydro-1h-inden-2-amine hydrochloride(1:1)
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Pfizer
Structure
Download
2D MOL

3D MOL

Formula
C17H28ClNO2
Canonical SMILES
CCCN(CCC)C1CC2=CC(=C(C=C2C1)OC)OC.Cl
InChI
1S/C17H27NO2.ClH/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;/h11-12,15H,5-10H2,1-4H3;1H
InChIKey
NMBUOXDBNWBGIM-UHFFFAOYSA-N
CAS Number
CAS 83598-46-3
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
H01BA02
SuperDrug CAS ID
cas=016679586
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Binder [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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