Drug Information

Drug General Information
Drug ID
D0T4PS
Former ID
DIB020261
Drug Name
LY 165,163
Synonyms
PAPP; LY-165163
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539133]
Structure
Download
2D MOL
Formula
C19H22F3N3
InChI
InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2
InChIKey
GAAKALASJNGQKD-UHFFFAOYSA-N
PubChem Compound ID
121930
PubChem Substance ID
795222, 6333886, 10239871, 11111756, 11413468, 15250266, 17405688, 24262978, 24278123, 26753653, 29302422, 46500433, 47589251, 47736779, 48334801, 50064554, 50107046, 50107047, 50904843, 53778238, 57339852, 85231213, 85788318, 90340652, 92303251, 103132653, 104414628, 117505147, 121361829, 123098328, 124750259, 124800165, 124881355, 124881356, 125543477, 127924210, 135076448, 135650543, 162227434, 163110011, 163565086, 178125578, 179235765, 198973003, 229944590
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534714]
5-hydroxytryptamine 6 receptor Target Info Agonist [533689]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
References
Ref 539133(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 18).
Ref 533689Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7.
Ref 534714Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56.

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