Drug Information

Drug General Information
Drug ID
D0T5KJ
Former ID
DNC012803
Drug Name
4-(3-Hydroxy-piperidin-3-yl)-benzene-1,2-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526729]
Structure
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2D MOL

3D MOL
Formula
C11H15NO3
Canonical SMILES
C1CC(CNC1)(C2=CC(=C(C=C2)O)O)O
InChI
1S/C11H15NO3/c13-9-3-2-8(6-10(9)14)11(15)4-1-5-12-7-11/h2-3,6,12-15H,1,4-5,7H2
InChIKey
REBGJGKBMBFBHE-UHFFFAOYSA-N
PubChem Compound ID
11820398
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [526729]
Alpha-1B adrenergic receptor Target Info Inhibitor [526729]
Alpha-1A adrenergic receptor Target Info Inhibitor [526729]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK SignalingWP58:Monoamine GPCRs
Endothelin Pathways
AMPK Signaling
References
Ref 526729J Med Chem. 1992 Mar 20;35(6):1009-18.Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.
Ref 526729J Med Chem. 1992 Mar 20;35(6):1009-18.Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.

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