Drug General Information
Drug ID	D0T5SU
Former ID	DNC004396
Drug Name	(S)-AMPA
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527890]
Structure		Download 2D MOL 3D MOL
Formula	C7H10N2O4
Canonical SMILES	CC1=C(C(=O)NO1)CC(C(=O)O)N
InChI	1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
InChIKey	UUDAMDVQRQNNHZ-YFKPBYRVSA-N
PubChem Compound ID	158397
Target and Pathway
Target(s)	Glutamate receptor AMPA subtype	Target Info	Inhibitor	[527890]
	Glutamate receptor 1	Target Info	Inhibitor	[527890]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Dopaminergic synapse
	Long-term depression
	Amyotrophic lateral sclerosis (ALS)
	Amphetamine addiction
	Nicotine addiction
PANTHER Pathway	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
Pathway Interaction Database	EPHB forward signaling
Reactome	COPII (Coat Protein 2) Mediated Vesicle Transport
	Trafficking of AMPA receptors
	Trafficking of GluR2-containing AMPA receptors
	Unblocking of NMDA receptor, glutamate binding and activation
	Cargo concentration in the ER
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Amyotrophic lateral sclerosis (ALS)
	BDNF signaling pathway
References
Ref 527890	J Med Chem. 2005 Dec 1;48(24):7867-81.Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Ref 527890	J Med Chem. 2005 Dec 1;48(24):7867-81.Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.