Drug General Information
Drug ID	D0T6JO
Former ID	DNC012054
Drug Name	Indol-1-yl-propyl-pyridin-4-yl-amine
Synonyms	Indol-1-yl-propyl-pyridin-4-yl-amine (Besipirdine)
Indication	Discovery agent		Investigative	[534087]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	CCCN(C1=CC=NC=C1)N2C=CC3=CC=CC=C32
InChI	1S/C16H17N3/c1-2-12-18(15-7-10-17-11-8-15)19-13-9-14-5-3-4-6-16(14)19/h3-11,13H,2,12H2,1H3
InChIKey	OTPPJICEBWOCKD-UHFFFAOYSA-N
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534087]
	Sodium channel protein type 5 subunit alpha	Target Info	Inhibitor	[525961]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534087]
	Sodium channel	Target Info	Inhibitor	[525961]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534087]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04261:Adrenergic signaling in cardiomyocyteshsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04728:Dopaminergic synapsehsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	Cardiac Progenitor DifferentiationWP58:Monoamine GPCRs
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 534087	J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Ref 525961	J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Ref 534087	J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.

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