Drug General Information
Drug ID
D0T6SC
Former ID
DIB020545
Drug Name
N-methylhistamine
Synonyms
1-methylhistamine; tele-methylhistamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538756]
Structure
Download
2D MOL
Formula
C6H11N3
InChI
InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3
InChIKey
FHQDWPCFSJMNCT-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H4 receptor Target Info Agonist [526144]
Histamine H3 receptor Target Info Agonist [535111]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
GPCRs, Class A Rhodopsin-like
References
Ref 538756(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1242).
Ref 526144Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30.
Ref 535111Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.

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