Drug Information

Drug General Information
Drug ID
D0T8LW
Former ID
DIB019519
Drug Name
compound 4g
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531363]
Formula
C22H16N4O
InChI
InChI=1S/C22H16N4O/c27-20(15-5-2-1-3-6-15)12-14-8-9-16-13-19(24-18(16)11-14)22-21-17(25-26-22)7-4-10-23-21/h1-11,13,24H,12H2,(H,25,26)
InChIKey
CDVMXMZPDJHSCC-UHFFFAOYSA-N
PubChem Compound ID
53322294
PubChem Substance ID
124967490, 125088219
Target and Pathway
Target(s) Tyrosine-protein kinase itk/tsk Target Info Inhibitor [531363]
KEGG Pathway Chemokine signaling pathway
T cell receptor signaling pathway
Leukocyte transendothelial migration
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
TCR signaling in na&#xef
Class I PI3K signaling events
Reactome Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
WikiPathways TCR Signaling Pathway
T-Cell Receptor and Co-stimulatory Signaling
TCR signaling
References
Ref 531363Optimisation of ITK inhibitors through successive iterative design cycles. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1852-6.
Ref 531363Optimisation of ITK inhibitors through successive iterative design cycles. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1852-6.

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