Drug General Information
Drug ID
D0TF9R
Former ID
DNC007850
Drug Name
2-(o-toluidino)-5-isopropylthiazol-4(5H)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529083]
Structure
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2D MOL

3D MOL

Formula
C13H16N2OS
Canonical SMILES
CC1=CC=CC=C1NC2=NC(=O)C(S2)C(C)C
InChI
1S/C13H16N2OS/c1-8(2)11-12(16)15-13(17-11)14-10-7-5-4-6-9(10)3/h4-8,11H,1-3H3,(H,14,15,16)
InChIKey
WTDVJQRSTXJXKV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [529083]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 529083Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61. Epub 2007 Sep 25.The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Ref 529083Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61. Epub 2007 Sep 25.The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.

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