Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U0BU
|
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| Former ID |
DNCL002250
|
||||
| Drug Name |
TOK-001
|
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| Drug Type |
Small molecular drug
|
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| Company |
Tokai Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C26H32N2O
|
||||
| InChI |
InChI=1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1
|
||||
| InChIKey |
PAFKTGFSEFKSQG-PAASFTFBSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Androgen receptor | Target Info | Inhibitor | [543224] | |
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Coregulation of Androgen receptor activity | |||||
| Regulation of Androgen receptor activity | |||||
| Nongenotropic Androgen signaling | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| FOXA1 transcription factor network | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
| Ref 532794 | Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor. Clin Cancer Res. 2014 Aug 1;20(15):4075-85. | ||||
| Ref 543224 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8638). | ||||
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