Drug General Information
Drug ID
D0U0XG
Former ID
DNC005908
Drug Name
N-(tert-butoxycarbonyl)-methionyl-glycine-nitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527885]
Structure
Download
2D MOL

3D MOL

Formula
C12H21N3O3S
Canonical SMILES
CC(C)(C)OC(=O)NC(CCSC)C(=O)NCC#N
InChI
1S/C12H21N3O3S/c1-12(2,3)18-11(17)15-9(5-8-19-4)10(16)14-7-6-13/h9H,5,7-8H2,1-4H3,(H,14,16)(H,15,17)/t9-/m0/s1
InChIKey
PDUKBZKBRGAZFC-VIFPVBQESA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin K Target Info Inhibitor [527885]
Cathepsin L Target Info Inhibitor [527885]
Cathepsin S Target Info Inhibitor [527885]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritishsa04142:Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Tuberculosis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_22:Leptin Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast SignalingWP2572:Primary Focal Segmental Glomerulosclerosis FSGSWP2796:Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.

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