Drug Information

Drug General Information
Drug ID
D0U1CL
Former ID
DIB013087
Drug Name
PGX-200097
Synonyms
COMT/dopamine D2 receptor inhibitors (schizophrenia), Psychiatric Genomics; Catechol-O-methyltransferase/dopamine D2 receptor inhibitors (schizophrenia), Psychiatric Genomics
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [548315]
Company
Psychiatric Genomics Inc
Target and Pathway
Target(s) Catechol-O-methyl-transferase Target Info Inhibitor [531048]
D(2) dopamine receptor Target Info Inhibitor [531048]
BioCyc Pathway L-dopa degradation
Dopamine degradation
Noradrenaline and adrenaline degradation
KEGG Pathway Steroid hormone biosynthesis
Tyrosine metabolism
Metabolic pathways
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Tyrosine Metabolism
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Methylation Pathways
Metapathway biotransformation
Estrogen metabolism
Biogenic Amine Synthesis
Dopamine metabolism
Phase II conjugation
Neurotransmitter Clearance In The Synaptic CleftWP666:Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 548315Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024498)
Ref 531048Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and future. Schizophr Res. 2010 Sep;122(1-3):1-23.

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