Drug General Information
Drug ID	D0U2CB
Former ID	DNC011692
Drug Name	Ibuproxam
Drug Type	Small molecular drug
Indication	Respiratory disease [ICD10:J00-J99]		Withdrawn from market	[533573]
Structure		Download 2D MOL 3D MOL
Formula	C13H19NO2
Canonical SMILES	CC(C)CC1=CC=C(C=C1)C(C)C(=O)NO
InChI	1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15)
InChIKey	BYPIURIATSUHDW-UHFFFAOYSA-N
PubChem Compound ID	68704
SuperDrug ATC ID	M01AE13
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[533474]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 533573	Anti-inflammatory agents: determination of ibuproxam and its metabolite humans. Correlation between bioavailability, tolerance and chemico-physical characteristics. Arzneimittelforschung. 1980;30(9):1607-9.
Ref 533474	J Med Chem. 1987 Nov;30(11):2121-6.In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.

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