Drug General Information
Drug ID
D0U3YB
Former ID
DAP000913
Drug Name
Masoprocol
Synonyms
Actinex; Masoprocolum; NDGA; CHX 100; N 5023; TNP00263; Actinex (TN); CHX-100; Masoprocol [USAN:INN]; Masoprocolum [INN-Latin]; Meso-NDGA; Meso-Nordihydroguaiaretic acid; Nordihydroguaiaretic acid from Larrea divaricata (creosote bush); Masoprocol (USAN/INN); Nordihydroguaiaretic acid (meso-form); Meso-4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; (R*,S*)-4,4'-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol; 4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Approved [467601], [536361]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL

Formula
C18H22O4
InChI
InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
InChIKey
HCZKYJDFEPMADG-UHFFFAOYSA-N
CAS Number
CAS 500-38-9
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
L01XX10
SuperDrug CAS ID
cas=027686846
Target and Pathway
Target(s) Receptor protein-tyrosine kinase erbB-2 Target Info Modulator [556264]
KEGG Pathway ErbB signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Focal adhesion
Adherens junction
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Bladder cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
EGF receptor signaling pathway
Pathway Interaction Database ErbB4 signaling events
ErbB2/ErbB3 signaling events
ErbB receptor signaling network
a6b1 and a6b4 Integrin signaling
Validated targets of C-MYC transcriptional repression
PathWhiz Pathway Phosphatidylinositol Phosphate Metabolism
Reactome SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
WikiPathways DNA Damage Response (only ATM dependent)
ErbB Signaling Pathway
EGF/EGFR Signaling Pathway
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Bladder Cancer
Signaling by ERBB2
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Semaphorin interactions
References
Ref 467601(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4265).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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