Drug Information

Drug General Information
Drug ID
D0U4EU
Former ID
DCL000224
Drug Name
SB-743921
Synonyms
N-[1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)propyl]-4-bromo-N-(3-dimethylaminopropyl)benzamide
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [521846], [530907]
Therapeutic Class
Anticancer Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C30H32BrClN4O2
Canonical SMILES
CCC(C1=NC2=C(C=CC(=C2)Cl)C(=O)N1CC3=CC=CC=C3)N(CCCN(C)C<br />)C(=O)C4=CC=C(C=C4)Br
InChI
1S/C30H32BrClN4O2/c1-4-27(35(18-8-17-34(2)3)29(37)22-11-13-23(31)14-12-22)28-33-26-19-24(32)15-16-25(26)30(38)36(28)20-21-9-6-5-7-10-21/h5-7,9-16,19,27H,4,8,17-18,20H2,1-3H3
InChIKey
PZVLDHUUSWUATQ-UHFFFAOYSA-N
PubChem Compound ID
11261882
PubChem Substance ID
16347332, 23437148, 42341399, 76918932, 91747702, 93580977, 103763442, 125721202, 140565437, 162839284, 163782397, 172649979, 196409693, 212342737, 237469092, 241071475, 242060245, 245044633
Target and Pathway
Target(s) Kinesin-like protein KIF11 Target Info Inhibitor [537212]
Reactome MHC class II antigen presentation
Kinesins
WikiPathways MHC class II antigen presentation
Kinesins
References
Ref 521846ClinicalTrials.gov (NCT00343564) A Study of SB-743921 in Non-Hodgkin's Lymphoma. U.S. National Institutes of Health.
Ref 530907A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54.
Ref 537212Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.

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