Drug General Information
Drug ID	D0U4TY
Former ID	DNC010609
Drug Name	4-cycloheptyl-6-propylpyrimidine-2-carbonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530717]
Structure		Download 2D MOL 3D MOL
Formula	C15H21N3
Canonical SMILES	CCCC1=NC(=NC(=C1)C2CCCCCC2)C#N
InChI	1S/C15H21N3/c1-2-7-13-10-14(18-15(11-16)17-13)12-8-5-3-4-6-9-12/h10,12H,2-9H2,1H3
InChIKey	UOAUUFFKQMFGTJ-UHFFFAOYSA-N
PubChem Compound ID	11694425
Target and Pathway
Target(s)	Cathepsin S	Target Info	Inhibitor	[530717]
	Cathepsin K	Target Info	Inhibitor	[530717]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Tuberculosishsa04142:Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritis
NetPath Pathway	Leptin Signaling Pathway
	IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentationR-HSA-1442490:Collagen degradation
	Activation of Matrix Metalloproteinases
	MHC class II antigen presentation
WikiPathways	Class I MHC mediated antigen processing & presentation
	Trafficking and processing of endosomal TLRWP2018:RANKL/RANK Signaling Pathway
	Osteoclast Signaling
References
Ref 530717	Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. Epub 2010 Jan 25.Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.
Ref 530717	Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. Epub 2010 Jan 25.Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.