Drug Information

Drug General Information
Drug ID
D0U5EY
Former ID
DIB016463
Drug Name
Org-37684
Synonyms
Org-36262
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [539062], [546616]
Company
Organon BioSciences
Structure
Download
2D MOL

3D MOL
Formula
C14H19NO2
InChI
InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3/t11-/m0/s1
InChIKey
QDJAYXYEXHVXJV-NSHDSACASA-N
CAS Number
CAS 213007-95-5
PubChem Compound ID
9794656
PubChem Substance ID
14749408, 15196263, 24104907, 44830675, 80663641, 129006580, 135650778, 136352575, 137144106, 139972383, 226604517
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [526325]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539062(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 171).
Ref 546616Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009204)
Ref 526325Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Apr;26(3):441-9.

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