Drug Information

Drug General Information
Drug ID
D0U5ML
Former ID
DNC008312
Drug Name
A-740003
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467462]
Structure
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2D MOL

3D MOL
Formula
C26H30N6O3
InChI
InChI=1S/C26H30N6O3/c1-26(2,3)24(31-23(33)15-17-11-12-21(34-4)22(14-17)35-5)32-25(29-16-27)30-20-10-6-9-19-18(20)8-7-13-28-19/h6-14,24H,15H2,1-5H3,(H,31,33)(H2,29,30,32)
InChIKey
PUHSRMSFDASMAE-UHFFFAOYSA-N
PubChem Compound ID
23232014
PubChem Substance ID
42431257, 103574511, 134224669, 134345517, 137096046, 152258816, 160647666, 162011857, 162249034, 163642749, 174531031, 176242915, 215784100, 229381170, 251962926, 252214636
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Inhibitor [530221]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 467462(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4119).
Ref 530221Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. Epub 2009 Jun 12.Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.

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