Drug Information

Drug General Information
Drug ID
D0U7DI
Former ID
DIB003777
Drug Name
SM-10661
Synonyms
SM-12502; SM-10661 (racemate); Rac-cis-3,5-Dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride; (+)-cis-(2R,5S)-3,5-Dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 2 [545724]
Structure
Download
2D MOL

3D MOL
Formula
C10H13ClN2OS
Canonical SMILES
CC1C(=O)N(C(S1)C2=CN=CC=C2)C.Cl
InChI
1S/C10H12N2OS.ClH/c1-7-9(13)12(2)10(14-7)8-4-3-5-11-6-8;/h3-7,10H,1-2H3;1H/t7-,10+;/m0./s1
InChIKey
CXHDSLQCNYLQND-XQRIHRDZSA-N
PubChem Compound ID
178014
PubChem Substance ID
10258832, 12014865, 15221044, 33501344, 57309863, 57395590, 78232683, 104426859, 135076730, 135155295, 227969815
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [531635], [534276]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 545724Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004382)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 534276Effect of the PAF-receptor antagonist SM-12502 on human platelets. Inflammation. 1996 Feb;20(1):71-85.

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